Comparative effects of systemic administration of levofloxacin and cephalexin on fracture healing in rats
Golestani Shayan, Golestaneh Arash, Gohari Atousa Aminzadeh,
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( Golestani Shayan ) - Islamic Azad University Dental School Department of Oral and Maxillofacial Surgery
( Golestaneh Arash ) - Islamic Azad University Dental School Department of Oral and Maxillofacial Surgery
( Gohari Atousa Aminzadeh ) - Islamic Azad University Dental School Department of Oral Pathology
Abstract
Objectives: This study aimed to compare the effects of systemic administration of levofloxacin or cephalexin on fracture healing in rats.
Materials and Methods: In this animal study, tibial fractures not requiring fixation were artificially induced in 30 male Wistar albino rats using a 1.1 mm surgical bur. The rats were randomly divided into 6 groups (n=5). Groups 1 and 2 received daily subcutaneous saline injections. Groups 3 and 4 received subcutaneous injections of 25 mg/kg levofloxacin twice daily. Groups 5 and 6 received daily subcutaneous injections of 20 mg/kg cephalexin. The rats in Groups 1, 3, and 5 were sacrificed after 1 week, while the rats in Groups 2, 4, and 6 were sacrificed after 4 weeks. The score of fracture healing was determined through histological assessment of sections from the fracture site according to Perry and colleagues. Data were analyzed by Kruskal?Wallis and Mann?Whitney tests.
Results: The mean score of fracture healing at 4 weeks was significantly higher than that at 1 week in the saline, levofloxacin, and cephalexin groups (P<0.001). At 1 week, no significant difference was noted among the three groups of saline, levofloxacin, and cephalexin in the mean score of fracture healing (P=0.360). However, this difference was significant at 4 weeks (P=0.018), and the mean score in the saline group was significantly higher com-pared to that in the levofloxacin group (P=0.015).
Conclusion: It is recommended not to prescribe levofloxacin for more than 1 week after surgical management of bone fractures due to its possible adverse effects on fracture healing.
키워드
Mandibular fractures; Bone regeneration; Levofloxacin; Cephalexin
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